However, agriculture declined through the twentieth century, and since the s a rapidly growing population, fed by families migrating in search of affordable housing, has led to more residential, industrial, and commercial development. Inexpensive land prices compared with Los Angeles and Orange Counties , a large supply of vacant land, and a transport network where many highways and railroads intersect have made the Inland Empire a major shipping hub. In federal crime statistics stated that San Bernardino was ranked the most dangerous city in California. The population of the Greater Los Angeles area which includes the Inland Empire is about 18 million people according to the United States Census , and is the second largest metropolitan region in the country. Views Read Edit View history. Air pollution, or suspended particulate matter locally generated from the increased number of automobiles in the area, from point sources such as factories, dust carried into the air by construction activity, and the contribution of similar pollutants from the Los Angeles area has regularly caused the Inland Empire to be at, or near, the bottom of many air quality ratings. Gangs, Drugs Invade Inland Empire".
Of the 23 trials they identified, 12 were methodologically sound enough to include in their analysis. The analysis revealed that some statistically significant weight loss occurred, but the magnitude of the effect is small and the clinical relevance is uncertain.
They also found that gastrointestinal adverse events were twice as likely in the hydroxycitric acid group as in the placebo group.